We aim to uncover the pathogenic mechanisms underlying neonatal developmental disorders such as lissencephaly, microcephaly, focal cortical dysplasia, and epilepsy, thereby advancing clinical diagnosis and treatment. Our lab has accumulated many research achievements and published them in well-reputed journals with high impact, including Nature, Nature Neuroscience, Nature genetics, Nature communications, Acta Neuropathologica, Development, The Journal of cell biology, and Epilepsia.
(1) Lissencephaly (more info.)
(2) Neural Stem Cells (more info.)
​(3) Transposon (more info.)

Why do malignant tumors develop in the brains of children during their developmental stages? Through cutting-edge imaging technologies and cerebellar electroporation methods, we aim to elucidate the pathogenic mechanisms underlying malignant brain tumors in children. Based on our current researches, we are actively developing potential anticancer drugs and advanced therapeutic strategies. In the past, our international collaboration with the Curie Institute in France has identified the role of transcription factors Atoh1 in regulating  primary cilium and carcinogenesis of cerebellar stem cells. This study has been published in best journal in the field of developmental biology《Developmental Cell》. (more info.)

Using two-photon microscopy, we can observe cells and ultra-structures located in the deep of tissues in living organisms. Our team has extensive user experience with state-of-the-art microscopy systems. We also improved cranial thinning technique, which facilitates long-term observation of neuronal morphology in the brains of live mice without inducing neuro-inflammation. This technique is particularly useful for studying neurodevelopmental disorders, allowing us to monitor changes in neuronal morphologies during critical developmental stages. Furthermore, it can be applied to the preclinical development of Alzheimer's disease treatments, enabling the evaluation of pathological changes before and after drug administration. Previously, we used this method to investigate pathological changes in the brains of mouse models of myotonic dystrophy. This study has been published in 《Neuropathology and Applied Neurobiology》and featured on the journal cover. (more info.)

Microglia, which defend against foreign pathogens and clear apoptotic cells, are not only vital guardians of the brain but also play a crucial role in dendritic spine development, neuroinflammation, and neuroprotection. Many neurological and psychiatric disorders associated with cognitive dysfunction are linked to disruptions in neuroimmune functions. Therefore, we focus on neuroimmune regulation mechanisms to elucidate the pathways of neurodegeneration and synaptic development abnormalities. Additionally, we collaborate with academic institutions and pharmaceutical companies to develop novel drugs.

(more info.)