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Publications

Journal Articles

Conference Paper

Selected Journal Articles

2025

1. Naher, S., Iemura, K., Miyashita, S., Hoshino, M., Tanaka, K., Niwa, S., Tsai, J. W., Kikkawa, T.* & Osumi, N.* (2025). Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex. The EMBO Journal, 44(2), 331-355.
2. Lin, T. Y., Wong, L. C., Hou, P. S., Wu, M. C. K., Cheng, H. Y., Zhao, M. H. J., ... Lee, W. T.* & Tsai, J. W.* Functional Defects in FOXG1 Variants Predict the Severity of Brain Anomalies in FOXG1 Syndrome. Molecular Psychiatry. (In press)

2024

1. Tsai, M. H., Lin, W. C., Chen, S. Y., Hsieh, M. Y., Nian, F. S., Cheng, H. Y., ... & Tsai, J. W.* (2024). A lissencephaly-associated BAIAP2 variant causes defects in neuronal migration during brain development. Development, 151(2), dev201912.

2. Tsai, M. H., Ke, H. C., Lin, W. C., Nian, F. S., Huang, C. W., Cheng, H. Y., ... & Tsai, J. W.* (2024). Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations. Acta Neuropathologica, 147(1), 13.

3. Lin, I. H., Li, Y. R., Chang, C. H., Cheng, Y. W., Wang, Y. T., Tsai, Y. S., ... Tsai, J. W.* & Wang, W. J.* (2024). Regulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth. Cell Death & Differentiation, 1-13.

4. Chang, C. H., Wong, L. C., Huang, C. W., Li, Y. R., Yang, C. W., Tsai, J. W.*, & Lee, W. T*. (2024). Pathogenic SHQ1 variants result in disruptions to neuronal development and the dopaminergic pathway. Experimental Neurology, 382, 114968.

5. Falnikar, A.*, Quintremil, S., Zhao, H. J., Cheng, H. Y., Helmer, P., Tsai, J. W., & Vallee, R. B.* (2024). The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells. Cell reports, 43(12).

2023

1. Huang, C. W., Lee, K. Y.*, Lin, P. T., Nian, F. S., Cheng, H. Y., Chang, C. H., ... & Tsai, J. W.* (2023). Muscleblind‐like 2 knockout shifts adducin 1 isoform expression and alters dendritic spine dynamics of cortical neurons during brain development. Neuropathology and Applied Neurobiology, 49(2), e12890.

2. Chung, C., Yang, X., Bae, T., Vong, K. I., Mittal, S., Donkels, C., ...Tsai, J. W., ...& Gleeson, J. G. (2023). Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development. Nature genetics, 55(2), 209-220.

2022

1. Lin, J. R., Cheng, J. F., Liu, Y. T., Hsu, T. R., Lin, K. M., Chen, C., ... & Tsai, J. W.* (2022). Novel lissencephaly‐associated DCX variants in the C‐terminal DCX domain affect microtubule binding and dynamics. Epilepsia, 63(5), 1253-1265.

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2020

1. Ibrahim, R. B., Yeh, S. Y., Lin, K. P., Ricardo, F., Yu, T. Y., Chan, C. C., ... Tsai, J. W.* & Liu, Y. T.* (2020). Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration. Cellular and Molecular Life Sciences, 77, 1421-1434.

2. Tsai, M. H., Muir, A. M., Wang, W. J., Kang, Y. N., Yang, K. C., Chao, N. H., ... Tsai, J. W.* & Mefford, H. C.* (2020). Pathogenic variants in CEP85L cause sporadic and familial posterior predominant lissencephaly. Neuron, 106(2), 237-245.

3. Tsai, M. H., Cheng, H. Y., Nian, F. S., Liu, C., Chao, N. H., Chiang, K. L., ... & Tsai, J. W.* (2020). Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation. Acta Neuropathologica Communications, 8, 1-17.

2019

1. Chang, C. H., Zanini, M., Shirvani, H., Cheng, J. S., Yu, H., Feng, C. H., ... Tsai, J. W.* & Ayrault, O.* (2019). Atoh1 controls primary cilia formation to allow for SHH-triggered granule neuron progenitor proliferation. Developmental Cell, 48(2), 184-199.

2. Chen, J. L., Chang, C. H., & Tsai, J. W.* (2019). Gli2 rescues delays in brain development induced by Kif3a dysfunction. Cerebral Cortex, 29(2), 751-764.

3. Ibrahim, R. B., Liu, Y. T., Yeh, S. Y., & Tsai, J. W.* (2019). Contributions of animal models to the mechanisms and therapies of transthyretin amyloidosis. Frontiers in Physiology, 10, 338.

4. Tsai, M. H., Nian, F. S., Hsu, M. H., Liu, W. S., Liu, Y. T., Liu, C., ... & Tsai, J. W.* (2019). PRRT2 missense mutations cluster near C‐terminus and frequently lead to protein mislocalization. Epilepsia, 60(5), 807-817.

5. Nian, F. S., Li, L. L., Cheng, C. Y., Wu, P. C., Lin, Y. T., Tang, C. Y., ... & Tsai, J. W.* (2019). Rab18 collaborates with Rab7 to modulate lysosomal and autophagy activities in the nervous system: An overlapping mechanism for warburg micro syndrome and charcot-marie-tooth neuropathy type 2B. Molecular Neurobiology, 56, 6095-6105.

6. Chang, H. Y., Cheng, H. Y., Tsao, A. N., Liu, C., & Tsai, J. W.* (2019). Multiple functions of KBP in neural development underlie brain anomalies in Goldberg-Shprintzen syndrome. Frontiers in Molecular Neuroscience, 12, 265.

2018

1. Jheng, G. W., Hur, S. S., Chang, C. M., Wu, C. C., Cheng, J. S., Lee, H. H., ... & Tsai, J. W.* (2018). Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration. Biochemical and biophysical research communications, 497(3), 869-875.

2. Lu, I. L., Chen, C., Tung, C. Y., Chen, H. H., Pan, J. P., Chang, C. H., ... & Tsai, J. W.* (2018). Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice. Nature Communications, 9(1), 2498.

3. Chen, Y. A., Lu, I. L., & Tsai, J. W.* (2018). Contactin-1/F3 regulates neuronal migration and morphogenesis through modulating RhoA activity. Frontiers in Molecular Neuroscience, 11, 422.

4. Hsiao, C. J., Chang, C. H., Ibrahim, R. B., Lin, I. H., Wang, C. H., Wang, W. J., & Tsai, J. W.* (2018). Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia. Journal of cell science, 131(24), jcs221218.

2016

1.Ma, L., Qiao, Q., Tsai, J. W., Yang, G., Li, W., & Gan, W. B.* (2016). Experience‐dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex. Developmental neurobiology, 76(3), 277-286.

2. Liu, Y. T., Nian, F. S., Chou, W. J., Tai, C. Y., Kwan, S. Y., Chen, C., ... & Tsai, J. W.* (2016). PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental defects. Oncotarget, 7(26), 39184.

3. Tsai, M. H., Kuo, P. W., Myers, C. T., Li, S. W., Lin, W. C., Fu, T. Y., ... Chang, Y. C.* & Tsai, J. W.* (2016). A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: genetic and functional studies. European Journal of Paediatric Neurology, 20(5), 788-794.

2011

1. Wang, X.*, Tsai, J. W., LaMonica, B., & Kriegstein, A. R.* (2011). A new subtype of progenitor cell in the mouse embryonic neocortex. Nature neuroscience, 14(5), 555-561.

2010

1. Tsai, J. W., Lian, W. N., Kemal, S., Kriegstein, A. R., & Vallee, R. B.* (2010). Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells. Nature neuroscience, 13(12), 1463-1471.

2009

1. Vallee, R. B.*, Seale, G. E., & Tsai, J. W. (2009). Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones. Trends in cell biology, 19(7), 347-355.

2. Wang, X., Tsai, J. W., Imai, J. H., Lian, W. N., Vallee, R. B., & Shi, S. H. (2009). Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature, 461(7266), 947-955.

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2007

1. Tsai, J. W., Bremner, K. H., & Vallee, R. B.* (2007). Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue. Nature neuroscience, 10(8), 970-979.

2006

1. Vallee, R. B.*, & Tsai, J. W. (2006). The cellular roles of the lissencephaly gene LIS1, and what they tell us aboutbrain development. Genes & development, 20(11), 1384-1393.

2005

1. Tsai, J. W., Chen, Y., Kriegstein, A. R., & Vallee, R. B.* (2005). LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages. The Journal of cell biology, 170(6), 935-945.

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Book Chapters

1. Huang, C. W., Su, Y. L., & Tsai, J. W.* (2024). Analysis of Neuronal Morphology by Two-Photon Microscopy. In Neuronal Morphogenesis: Methods and Protocols (pp. 81-95). New York, NY: Springer US.

2. Cheng, H. Y., Nian, F. S., Ou, Y. W., & Tsai, J. W.* (2023). Assessment of Dynein-Mediated Nuclear Migration in the Developing Cortex by Live-Tissue Microscopy. In Dynein: Methods and Protocols (pp. 61-71). New York, NY: Springer US.

3. Tsai, J. W., & Vallee, R. B.* (2011). Live microscopy of neural stem cell migration in brain slices. Stem Cell Migration: Methods and Protocols, 131-142.

Selected Conference Papers

1. Tamayanti, W. D., Lin, J. R., Ariyanti, A. D., Chang, Y., Cheng, H. Y., Huang, C. W., ..., Tsai, J. W. & Chen, H. K.* (2024). Safety of the CSF1R Inhibitor EI‐1071 in Human and Its Pharmacological Effects to Reduce Neuroinflammation and Improve Memory Function in a Mouse Model of Alzheimer’s Disease. Alzheimer's & Dementia, 20, e091161.

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